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This paper presents a high linearity operational transconductance amplifier (OTA) based on pseudo-differential structures. The linearity is improved by mobility compensation techniques as the device size is scaled down to achieve high speed operation. Transconductance tuning could be achieved by a MOS operating in the linear region. The OTA fabricated in the TSMC 0.18-mum CMOS process occupies a small area of 4.5 times 10-3 mm2. The measured third-order inter-modulation (IM3) distortion under 1-V power supply voltage remains below -52 dB up to 50 MHz for a 400 mV pp differential input. The static power consumption is 2.5 mW. Experimental results demonstrate the agreement with theoretical analyses.