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Human-observer LROC study of lesion detection in Ga-67 SPECT images reconstructed using MAP with anatomical priors

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8 Author(s)
Lehovich, A. ; Div. of Nucl. Medicine, Univ. of Massachusetts Med. Sch., Worcester, MA ; Bruyant, P.P. ; Gifford, H.C. ; Schneider, P.B.
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We compare the image quality of SPECT reconstruction with and without an anatomical prior. Area under the localization-response operating characteristic (LROC) curve is our figure of merit. Simulated Ga-67 citrate images, a SPECT lymph-nodule imaging agent, were generated using the MCAT digital phantom. Reconstructed images were read by human observers. Several reconstruction strategies are compared, including rescaled block iterative (RBI) and maximum-a-posteriori (MAP) with various priors. We find that MAP reconstruction using prior knowledge of organ and lesion boundaries significantly improves lesion-detection performance (p < 0.05). Pseudo-lesion boundaries, regions without increased uptake which are incorrectly treated as prior knowledge of lesion boundaries, do not decrease performance.

Published in:

Nuclear Science Symposium Conference Record, 2006. IEEE  (Volume:3 )

Date of Conference:

Oct. 29 2006-Nov. 1 2006