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VLSI Potentiostat Array With Oversampling Gain Modulation for Wide-Range Neurotransmitter Sensing

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5 Author(s)
Milutin Stanacevic ; Dept. of Electr. & Comput. Eng., Stony Brook Univ., NY ; Kartikeya Murari ; Abhishek Rege ; Gert Cauwenberghs
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A 16-channel current-measuring very large-scale integration (VLSI) sensor array system for highly sensitive electrochemical detection of electroactive neurotransmiters like dopamine and nitric-oxide is presented. Each channel embeds a current integrating potentiostat within a switched-capacitor first-order single-bit delta-sigma modulator implementing an incremental analog-to-digital converter. The duty-cycle modulation of current feedback in the delta-sigma loop together with variable oversampling ratio provide a programmable digital range selection of the input current spanning over six orders of magnitude from picoamperes to microamperes. The array offers 100-fA input current sensitivity at 3.4-muW power consumption per channel. The operation of the 3 mm times3 mm chip fabricated in 0.5-mum CMOS technology is demonstrated with real-time multichannel acquisition of neurotransmitter concentration

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IEEE Transactions on Biomedical Circuits and Systems  (Volume:1 ,  Issue: 1 )