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An optimization based treatment planning system for interstitial thermo-radiotherapy and thermal ablation

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4 Author(s)
Khalil, I.S. ; California Univ., Berkeley, CA, USA ; Diederich, C.J. ; Kirjner-Neto, C. ; Dutton, A.W.

The following work is part of our ongoing efforts to develop a robust and efficient optimization based treatment planning system for interstitial thermo-radiotherapy and thermal ablation procedures for cancer treatment. We formulate a minimax based optimization system to determine catheter placements, radioactive source strengths, and power settings of heating applicators needed to deliver a prescribed dose distribution. Using interstitial ultrasound applicators, we demonstrate the feasibility of this approach in thermal therapy for treating a brain tumor. The proposed optimization approach ensures robustness with respect to the dose prescriptions and provides a clinically relevant measure to quantify the merit of the treatment plan

Published in:

Engineering in Medicine and Biology Society, 1994. Engineering Advances: New Opportunities for Biomedical Engineers. Proceedings of the 16th Annual International Conference of the IEEE

Date of Conference:

1994