By Topic

4J-2 Ultrasound-Based Thermal and Elasticity Imaging to Assist Photothermal Cancer Therapy - Preliminary Study

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

5 Author(s)
Jignesh Shah ; Dept. of Biomed. Eng., Texas Univ., Austin, TX ; Aglyamov, S.R. ; Sokolov, K. ; Milner, T.E.
more authors

Photothermal therapy is a targeted, non-invasive thermal treatment of cancer. Up to 40 degC temperature increase is obtained in a small volume of malignant cells by using appropriate photoabsorbers and irradiating the tissue with a continuous wave laser. However, in order to ensure successful outcome of photothermal therapy, the tumor needs to be imaged before therapy, the temperature needs to be monitored during therapy and, finally, the tumor needs to be evaluated for necrosis during and after therapy. We investigated the feasibility of ultrasound imaging to track temperature changes during photothermal therapy and elasticity imaging to monitor tumor necrosis after treatment. The image-guided therapy was demonstrated on tissue mimicking phantoms and ex-vivo animal tissue with gold nanoparticles as photoabsorbers. Ultrasound-based thermal imaging effectively generates temperature maps during therapy while elasticity imaging monitors changes in the mechanical properties of tissue before and after therapy, allowing evaluation of treatment efficacy. Results of our study suggest that ultrasound can be used to guide photothermal therapy

Published in:

Ultrasonics Symposium, 2006. IEEE

Date of Conference:

2-6 Oct. 2006