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In recent years, Internet worms increasingly threaten the Internet hosts and service and polymorphic worms can evade signature-based intrusion detection systems. In this paper, we propose new methods to detect polymorphic worms based on semantic signature and data-mining. Our main contributions of this work are as follows: (1) we propose a worm attack model - the OSJUMP model. (2) Based on the attack model, we analyse the feature of polymorphic worms and the feature of perfect ones. (3) We propose methods to detect worms through recognizing JUMP address based on data-mining such as Bayes and ANN. We evaluate some famous worm and polymorphic ones generated from them. The results show that the false negative and performance improved a lot compared to signature-based IDSs.