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Adaptive resource management has become a key technique for the next-generation wireless systems. In this paper, we propose a cross-layer adaptive resource allocation and scheduling approach for downlink multiuser OFDM systems. Different from adaptive resource allocation schemes proposed earlier, the distinctive feature of the cross-layer optimization methodology is the joint design of the multiuser subcarrier, bit and power allocation in the physical layer along with the packet scheduling in the data link layer. Simulations results show that the proposed cross-layer optimization and design approach achieves significant gains in both throughput and average packet delay compared to the traditional resource allocation scheme without consideration of the cross-layer interactions.