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Finite-Element Modeling of Cell Exposed to Harmonic and Transient Electric Fields

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4 Author(s)
I. Meny ; Ecole Centrale de Lyon, Ecully ; N. Burais ; F. Buret ; L. Nicolas

The transmembrane potential (TMP) of a cell exposed to harmonic or transient electric fields is the main parameter for a successful permeabilization of a cell. Obviously, TMP can be computed with a finite-element method, but the high contrast between sizes and electromagnetic properties of the cytoplasm, the membrane, and the extra-cellular medium leads sometimes to inaccurate numerical results. Influences of membrane conductivity and frequency on the accuracy are studied. Optimization of transient waveforms is proposed for various shapes of cells

Published in:

IEEE Transactions on Magnetics  (Volume:43 ,  Issue: 4 )