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Finite-Element Modeling of Cell Exposed to Harmonic and Transient Electric Fields

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4 Author(s)
Meny, I. ; Ecole Centrale de Lyon, Ecully ; Burais, N. ; Buret, F. ; Nicolas, L.

The transmembrane potential (TMP) of a cell exposed to harmonic or transient electric fields is the main parameter for a successful permeabilization of a cell. Obviously, TMP can be computed with a finite-element method, but the high contrast between sizes and electromagnetic properties of the cytoplasm, the membrane, and the extra-cellular medium leads sometimes to inaccurate numerical results. Influences of membrane conductivity and frequency on the accuracy are studied. Optimization of transient waveforms is proposed for various shapes of cells

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Magnetics, IEEE Transactions on  (Volume:43 ,  Issue: 4 )