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Browse Journals & Magazines > Biomedical Engineering, IEEE ...> Volume:BME-27 Issue:9 Help

Systems and Microcomputer Approach to Anticoagulant Therapy

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3 Author(s)
Powers, W.F. ; Department of Aerospace Engineering and the Program in Computer, Information, and Control Engineering, University of Michigan ; Abbrecht, Peter H. ; Covell, David G.

A modem systems approach to the warfarin (an oral anticoagulant drug) dosage control problem is developed and analyzed on numerous patient data sets. Except for the initial statistics generation, all of the computer programs are developed for the relatively inexpensive Commodore PET 2001 microcomputer. A stabilized extended Kalman filter is employed to determine two patient dependent parameters from a series of Quick prothrombin time measurements in addition to estimating the prothrombin complex activity. The resultant parameters are then employed in an interactive graphics simulation program to determine a near-optimal dosage strategy.

Published in:
Biomedical Engineering, IEEE Transactions on  (Volume:BME-27 ,  Issue: 9 )

Date of Publication: Sept. 1980

Page(s):
520 - 523
ISSN :
0018-9294
Digital Object Identifier :
10.1109/TBME.1980.326667
Product Type:
Journals & Magazines
Date of Current Version :
12 March 2007
Issue Date :
Sept. 1980
Sponsored by :
IEEE Engineering in Medicine and Biology Society
PubMed ID :
7409826

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