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Automatic Continuous-Time Blood Pressure Control in Dogs by Means of Hypotensive Drug Injection

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1 Author(s)
Koivo, Antti J. ; School of Electrical Engineering, Purdue University

An automated drug administration system is proposed to control the decrease in the mean arterial blood pressure of dogs. It is accomplished by identifying a model for the open loop system consisting of a syringe pump and a dog. A linear feedback controller is then determined by solving an inverse optimum control problem. The chosen controller is optimal relative to a quadratic critexion. The controller is designed so that the mean arterial blood pressure is maintained at a desired level.

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Biomedical Engineering, IEEE Transactions on  (Volume:BME-27 ,  Issue: 10 )