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Is it Possible to Analyze DNA and Protein Sequences by the Methods of Digital Signal Processing?

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4 Author(s)
Veljkovic, V. ; Laboratory for Theoretical Physics, Boris Kidri¿Institute of Nuclear Sciences ; Cosic, I. ; Dimitrijevic, ; Lalovic, D.

Informational content of linear macromolecules (DNA, RNA, and proteins) is analyzed by the method of digital signal processing. Each element (amino acid or nucleotide) of macromolecules is represented by the corresponding value of electron-ion interaction potential. This numerical representation of the primary structure of macromolecules is subjected to digital signal processing in order to extract the information corresponding to biological function. It is shown that the multiple cross spectrum of functionally related sequences exhibits significant peak frequencies. In the case of functionally unrelated sequences such peaks were not found. Peak frequencies are different for different biological functions. Based on this, we conjecture that the peak frequencies in the multiple cross spectrum of sequences with the same boilogical function are related to this biological function.

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Biomedical Engineering, IEEE Transactions on  (Volume:BME-32 ,  Issue: 5 )