Scheduled System Maintenance:
Some services will be unavailable Sunday, March 29th through Monday, March 30th. We apologize for the inconvenience.
By Topic

The Action Potential Clamp as a Test of Space-Clamp Effectiveness - The Lettvin Analog Axon

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

2 Author(s)
Starzak, Michael ; Department of Chemistry, State University of New York ; Needle, Michael

For a Lettvin analog axon, in which spurious currents due to inadequate space clamp are absent, the action potential clamp technique accurately reproduces the original stimulating current. The action potential generated for the first phase of the experiment is stored digitally. When this action potential waveform is used for the voltage clamp phase of the experiment, digital noise in the resultant current record is a factor of ten smaller than that of the reproduced current record. The requirement of rapid transition between the two experimental components for such experiments with squid giant axon is examined.

Published in:

Biomedical Engineering, IEEE Transactions on  (Volume:BME-30 ,  Issue: 2 )