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Essential design factors and system characteristics are explored for integration of large power systems into manned space stations. The impact of the type of power system selected upon the space station is outlined, as is the impact of the mission requirements upon the selection of power systems. Criteria for resolving the selection/application/ integration problems are provided. Comparisons between systems are based on recently defined space-station models for 90-day to five-year mission durations in the 1970' s, with four-to nine-man crews. Power systems encompass power levels from 3 to 50 kWe and include solar cell/battery. fuel cell, hybrid fuel cell/solar cell, radioisotope, and nuclear reactor systems. Thermoelectric, Brayton cycle, organic Rankine, and liquid-metal Rankine power conversion systems are considered for the nuclear energy sources. Both rigid and roll-out photovoltaic array configurations are analyzed with respect to the solar energy source.