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The task of optimizing a complex system presents at least two levels of problems for the system designer. First, a class of optimization algorithms must be chosen that is suitable for application to the system. Second, various parameters of the optimization algorithm need to be tuned for efficiency. A class of adaptive search procedures called genetic algorithms (GA) has been used to optimize a wide variety of complex systems. GA's are applied to the second level task of identifying efficient GA's for a set of numerical optimization problems. The results are validated on an image registration problem. GA's are shown to be effective for both levels of the systems optimization problem.