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With the use of computers several mathematical techniques can be applied to aid certain aspects of medical diagnosis. However, much work remains to be accomplished in trying these methods under practical conditions. Although wide interest has been expressed, few studies have been reported in the literature. Among the potential advantages of computer aids are: making available to the physician quantitative methods in areas related to data analysis and differential diagnosis; assisting in the evaluation of the best alternative courses of action during stages of the diagnostic testing processes; and periodic recording and evaluating of individual physiologic norms for more sensitive determination of an individual's health trend relative to disease prevention. Communication between the physician or researcher and the computer is presently technically feasible but much research and planning are still required for realistic application.