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CMOS-Based Phase Fluorometric Oxygen Sensor System

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6 Author(s)
Chodavarapu, Vamsy P. ; Dept. of Electr. Eng., State Univ. of New York, Buffalo, NY ; Shubin, D.O. ; Bukowski, R.M. ; Titus, A.H.
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The design and development of a phase fluorometric oxygen (O2 ) sensor system using single-chip CMOS detection and processing integrated circuit (DPIC) and sol-gel derived xerogel thin-film sensor elements is described. The sensor system determines analyte concentrations using the excited state lifetime measurements of an O2-sensitive luminophore (tris(4,7-diphenyl-1,10- phenathroline)ruthenium (II)) embedded in the xerogel matrix. A light emitting diode (LED) is used as the excitation source, and the fluorescence is detected by the DPIC using a 16times16 phototransistor array on-chip. The DPIC also consists of a current mirror, current-to-voltage converter, amplifier, bandpass filter, and phase detector. The DPIC output is a dc voltage that corresponds to the detected fluorescence phase shift. With a 14-kHz modulation frequency, the entire system including driving the LED consumes 80 mW of average power. The sensor system provides stable, reproducible, analytically reliable, and fast response (~20 s) to changes in the gaseous oxygen concentrations and establishes the viability for low cost, low power and miniaturized biochemical sensor systems

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Circuits and Systems I: Regular Papers, IEEE Transactions on  (Volume:54 ,  Issue: 1 )