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A model of B-lymphocyte stimulation and associated antibody production is used to simulate treatment and the course of Systematic lupus erythematosis (SLE). Some of the most severe symptoms of the disease are thought to be consequences of the production of antibody against our own DNA(SLE is an "autoimmune" disease). Treatment consists of minimizing organ damage by suppressing the production of antibody (by suppressing all the components of the immune response) and maintaining the patient in a stable condition. The effect of treatment in use and the existence of a stable equilibrium is demonstrated in the model.
Decision and Control including the 17th Symposium on Adaptive Processes, 1978 IEEE Conference on (Volume:17 )
Date of Conference: Jan. 1978