Cart (Loading....) | Create Account
Close category search window
 

Efficient Detection of Network Motifs

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

1 Author(s)
Wernicke, S. ; Inst. fur Informatik, Friedrich-Schiller-Univ., Jena

Motifs in a given network are small connected subnetworks that occur in significantly higher frequencies than would be expected in random networks. They have recently gathered much attention as a concept to uncover structural design principles of complex networks. Kashtan et al. [Bioinformatics, 2004] proposed a sampling algorithm for performing the computationally challenging task of detecting network motifs. However, among other drawbacks, this algorithm suffers from a sampling bias and scales poorly with increasing subgraph size. Based on a detailed analysis of the previous algorithm, we present a new algorithm for network motif detection which overcomes these drawbacks. Furthermore, we present an efficient new approach for estimating the frequency of subgraphs in random networks that, in contrast to previous approaches, does not require the explicit generation of random networks. Experiments on a testbed of biological networks show our new algorithms to be orders of magnitude faster than previous approaches, allowing for the detection of larger motifs in bigger networks than previously possible and thus facilitating deeper insight into the field

Published in:

Computational Biology and Bioinformatics, IEEE/ACM Transactions on  (Volume:3 ,  Issue: 4 )

Date of Publication:

Oct.-Dec. 2006

Need Help?


IEEE Advancing Technology for Humanity About IEEE Xplore | Contact | Help | Terms of Use | Nondiscrimination Policy | Site Map | Privacy & Opting Out of Cookies

A not-for-profit organization, IEEE is the world's largest professional association for the advancement of technology.
© Copyright 2014 IEEE - All rights reserved. Use of this web site signifies your agreement to the terms and conditions.