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CMOS DNA Sensor Array With Integrated A/D Conversion Based on Label-Free Capacitance Measurement

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10 Author(s)

This paper presents a fully electronic label-free DNA chip in 0.5-mum CMOS technology, with 5-V supply voltage, suitable for low-cost highly integrated applications. The chip features an array of 128 sensor sites with gold electrodes and integrated measurement, conditioning, multiplexing and analog-to-digital conversion circuitry. The circuits measure capacitance variations due to DNA hybridization on the gold electrodes which are bio-modified by covalently attaching probes of known sequence. Specificity, repeatability and parallel detection capability of the fabricated chip are successfully demonstrated

Published in:

IEEE Journal of Solid-State Circuits  (Volume:41 ,  Issue: 12 )