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This paper presents a fully electronic label-free DNA chip in 0.5-mum CMOS technology, with 5-V supply voltage, suitable for low-cost highly integrated applications. The chip features an array of 128 sensor sites with gold electrodes and integrated measurement, conditioning, multiplexing and analog-to-digital conversion circuitry. The circuits measure capacitance variations due to DNA hybridization on the gold electrodes which are bio-modified by covalently attaching probes of known sequence. Specificity, repeatability and parallel detection capability of the fabricated chip are successfully demonstrated
Published in:
Solid-State Circuits, IEEE Journal of
(Volume:41
,
Issue:
12
)
Date of Publication: Dec. 2006
- Page(s):
- 2956 - 2964
- ISSN :
- 0018-9200
- INSPEC Accession Number:
- 9193696
- Digital Object Identifier :
- 10.1109/JSSC.2006.884867
- Product Type:
- Journals & Magazines
- Date of Current Version :
- 20 November 2006
- Issue Date :
- Dec. 2006
- Sponsored by :
- IEEE Solid-State Circuits Society
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