Cart (Loading....) | Create Account
Close category search window
 

Protein fold recognition from secondary structure assignments

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

3 Author(s)
Russell, R.B. ; Lab. of Molecular Biophys., Oxford, UK ; Copley, R.R. ; Barton, G.J.

A method for finding protein folds consistent with secondary structure assignments and imposed experimental restraints is described. All possible matches between the query pattern and every member of a database of protein structural domains are generated by a comparison of secondary structure assignments. The comparison allows for errors in predicted secondary structure elements and possible variations between query and database structure. Several filters remove matches that are un-compact, that have poor β sheet bonding, that do not allow loop/turn lengths to bridge the distance between connected secondary structures, or that fail to satisfy imposed experimental restraints (e.g. disulphide bonds). The remaining matches provide a set of plausible topologies for a protein of unknown structure, which can be inspected visually or tested by experiment. A search using the src homology 2 domain prediction finds 13 possible topologies, one being a domain from the E. coli bio protein known to adopt an SH2 fold. The use and development of the method are discussed

Published in:

System Sciences, 1995. Proceedings of the Twenty-Eighth Hawaii International Conference on  (Volume:5 )

Date of Conference:

3-6 Jan 1995

Need Help?


IEEE Advancing Technology for Humanity About IEEE Xplore | Contact | Help | Terms of Use | Nondiscrimination Policy | Site Map | Privacy & Opting Out of Cookies

A not-for-profit organization, IEEE is the world's largest professional association for the advancement of technology.
© Copyright 2014 IEEE - All rights reserved. Use of this web site signifies your agreement to the terms and conditions.