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Practical use of a fully automatic homology-based protein modelling protocol

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2 Author(s)
Platt, E. ; Proteus Molecular Design Ltd., Macclesfield, UK ; Robson, B.

Like secondary structure prediction, we believe that tertiary structure prediction should also be automatic, and hence reproducible. A fully automatic protocol called HOM FOLD, for modelling proteins by homology using a fragment-based approach, is described. This paper describes the performance of the basic algorithm. Written in the GLOBAL language, it is a simple matter to add further knowledge and expertise as new rules in the protocol. The protocol was intended to be, and is normally used as, a first step only, with more elaborate algorithms for energy refinement to be applied subsequently in the context of a higher-level protocol. However, structures in agreement within 1.80 Å X-ray crystallographic data can be achieved that are at least as good as that obtained by interactive modelling and refinement

Published in:

System Sciences, 1995. Proceedings of the Twenty-Eighth Hawaii International Conference on  (Volume:5 )

Date of Conference:

3-6 Jan 1995