Cart (Loading....) | Create Account
Close category search window

A hybrid algorithm for determining protein structure

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

1 Author(s)
Xiru Zhang ; PHZ Partners, Cambridge, MA, USA

At Thinking Machines, my colleagues and I have developed a hybrid system combining a neural network, a statistical module, and a memory-based reasoner, each of which makes its own prediction. A combiner then blends these results to produce the final predictions. This hybrid system improves its ability to determine how amino acid sequences fold into 3D protein structures. It predicts secondary structures with 66.4% accuracy. Both the neural network and the combiner are multilayer perceptrons trained with the standard backpropagation algorithm; this article focuses on the other two components, and on how we trained the hybrid system and used it for prediction. I also discuss how future work in AI and other sciences might meet the challenge of the protein folding problem.<>

Published in:

IEEE Expert  (Volume:9 ,  Issue: 4 )

Date of Publication:

Aug. 1994

Need Help?

IEEE Advancing Technology for Humanity About IEEE Xplore | Contact | Help | Terms of Use | Nondiscrimination Policy | Site Map | Privacy & Opting Out of Cookies

A not-for-profit organization, IEEE is the world's largest professional association for the advancement of technology.
© Copyright 2014 IEEE - All rights reserved. Use of this web site signifies your agreement to the terms and conditions.