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Enzymatic activity of plasmin in strong magnetic fields

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2 Author(s)
Iwasaka, M. ; Inst. of Med. Electron., Tokyo Univ. ; Ueno, S.

We investigated the effects of magnetic fields on the enzymatic activity of plasmin concerning the dissolution of thrombosis. Plasmin activity in magnetic fields up to 8 T was assessed using a synthetic substrate for plasmin, D-Val-Leu-Lys-pNA. We observed that the initial rate of the reaction accelerated 5% in an 8 T magnetic field. We also measured time courses of the reaction. When the absorbance changed non-linearly and reached 60-90% of the maximum absorbance, absorbance of the mixture exposed to an 8 T magnetic field at 37°C was 7-11% lower than control samples. The results show that the enzymatic activity of plasmin was affected by a magnetic field at 8 T. This suggests that magnetic fields have an effect on the active center of the reaction of plasmin with a substrate, especially on the hydrogen bonds of the charge-relay system

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Magnetics, IEEE Transactions on  (Volume:30 ,  Issue: 6 )