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Time-resolved reflectance: a systematic study for application to the optical characterization of tissues

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5 Author(s)
Cubeddu, R. ; Politecnico di Milano, Italy ; Musolino, M. ; Pifferi, A. ; Taroni, P.
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In principle, the measurement of the time-resolved diffuse reflectance, as interpreted on the basis of the diffusion theory, allows one to determine the optical properties (absorption coefficient μα and transport scattering coefficient μ's ) of biological materials noninvasively. A system for time-resolved reflectance measurements and its performances are described in detail. An extensive experimental work and a computer simulation characterized the influence of μα, μ' s, and observation distance on the measurement, and allowed to determine the ranges of μα and μ's which can be measured reliably (and which include most of the values of interest in biomedical applications). Moreover, on the basis of the experimental and computer work, the optimal experimental parameters can be determined in various situations. The results presented are general and can be extended to different systems of measurement

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Quantum Electronics, IEEE Journal of  (Volume:30 ,  Issue: 10 )