By Topic

Engineering automated systems for physical mapping

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$33 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

3 Author(s)
S. J. Gordon ; Intelligent Automation Systems Inc., USA ; A. J. Christopher ; J. L. Valle

The automated physical mapping system described here is currently being used to complete physical maps of both the human and the mouse genomes. The originally targeted 5,000 screenings per day has been surpassed with about 18,000 daily screenings on a routine basis. Thus far, 3,500 STSs have been mapped and the remaining 6,500 required to make the first low-density STS physical map are likely to be completed very early in 1995. Many of the biochemical and automation techniques used for this physical mapping project may also have applications in other areas such as DNA genotyping, and DNA diagnostics. For example, it may be possible to screen large populations for particular genetic diseases (such as cystic fibrosis and a propensity for certain cancers) before they exhibit any symptoms, thereby allowing potential treatments to start as early as possible.<>

Published in:

IEEE Engineering in Medicine and Biology Magazine  (Volume:13 ,  Issue: 4 )