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Pharmocokinetics of dicarboxylic acids in man

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5 Author(s)
Bertuzzi, A. ; Istituto di Analisi dei Sistemi ed Inf., CNR, Rome, Italy ; Gandolfi, A. ; Salinari, S. ; Mingrone, G.
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In order to study the feasibility of using dicarboxylic acids for parenteral nutrition, the authors studied the pharmacokinetics in man of azelaic acid and sebacic acid. The pharmacokinetic analysis presented here shows that there are different modalities in the urinary excretion of the dicarboxylic acids with 9 or 10 carbon atoms. While azelaic acid seems to be actively secreted, sebacic acid is actively reabsorbed.<>

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Engineering in Medicine and Biology Magazine, IEEE  (Volume:13 ,  Issue: 4 )