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Activity quantitation in SPECT: a comparison of three attenuation correction methods in combination with pre-reconstruction restoration filtering

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3 Author(s)
King, M.A. ; Dept. of Nucl. Med., Massachusetts Univ., Med. Center, Worcester, MA, USA ; Glick, S.J. ; Penney, B.C.

A study of activity quantitation with pre-reconstruction Metz filtering and the use of arithmetic mean pre-reconstruction, Chang's post-reconstruction, or Bellini's intrinsic attenuation correction was conducted. Tc-99m-Filled spheres of various diameters were used to study activity estimation with an elliptical cross-section phantom. The percent of air sensitivity, which is calculated as the count rate for an ROI (region of interest) per unit activity for a source in the phantom divided by the count rate per unit activity for a point source in air times 100%, was used to assess the accuracy of attenuation correction. It was determined that a transmission model which explicitly included the buildup of scattered radiation yielded more accurate quantitation of activity in a uniform tub than correcting for scatter by scaling the counts with an average scatter fraction. The use of 2-D pre-reconstruction Metz filteringcombined with Bellini's intrinsic or Chang's post-reconstruction attenuation correction resulted in percent sensitivities which were the least position dependent and closest to 100%

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Nuclear Science, IEEE Transactions on  (Volume:38 ,  Issue: 2 )