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A tomographic simulation technique for evaluating quantitative limitations of myocardial PET studies

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5 Author(s)
Hutchins, G.D. ; Div. of Nucl. Med., Michigan Univ., MI, USA ; Caraher, J. ; Murphy, B. ; Wolfe, E.
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A three-dimensional simulation method has been developed for evaluating the potential to quantify myocardial function with PET (positron emission tomography) using a three-dimensional beating heart phantom. Expected tracer kinetics are assigned regionally throughout the heart phantom and tomographic simulation methods are utilized to form a dynamic sequence of images. Analysis of the simulated data using standard kinetic evaluation tools provides estimates of bias and variance in the kinetic parameters as a function of emission and transmission scan statistics, image scatter fraction, and placement of regions of interest. Comparison of the simulation results with measured PET data demonstrates the validity of the simulation approach and its application in the evaluation of quantitative myocardial PET studies.<>

Published in:

Nuclear Science Symposium and Medical Imaging Conference, 1991., Conference Record of the 1991 IEEE

Date of Conference:

2-9 Nov. 1991