In quantitative computed tomography (QCT), time serial measurements are performed to detect a global bone density loss or to identify localized bone density changes. A prerequisite for an unambiguous analysis is the comparison of identical bone volumes. Usually, manual repositioning is too coarse. A mathematical procedure that allows matching two three-dimensional image volumes is presented. The algorithm is based on correlation techniques. The procedure has been optimized and applied to computer-tomographic 3-D images of the human knee. It has been tested with both artificially created and in vivo measured image data. Typical differential images calculated from real bone measurements are presented
Published in:
Medical Imaging, IEEE Transactions on
(Volume:12
,
Issue:
3
)
Date of Publication: Sep 1993