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Optimal insulin infusion resulting from a mathematical model of blood glucose dynamics

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2 Author(s)
M. E. Fisher ; Dept. of Math., Western Australia Univ., Nedlands, WA, Australia ; K. L. Teo

The application of mathematical optimization techniques to a simplified mathematical model of blood glucose dynamics to derive insulin infusion programs for the control of blood glucose levels in diabetic individuals is discussed. Two particular cases are discussed: first, that of the insulin infusion program which results in an initially high blood glucose level being reduced to acceptable levels; secondly, that of the control of blood glucose levels following a meal, prior to which blood glucose and net blood-glycemic hormone were at their fasting levels.<>

Published in:

IEEE Transactions on Biomedical Engineering  (Volume:36 ,  Issue: 4 )