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Magnetic Resonance and Light Microscopy Investigation of Raw Cells Treated With Dextran-Based Magnetic Fluid

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12 Author(s)
Lacava, Z.G.M. ; Inst. de Biologia, Univ. de Brasilia ; Lacava, L.M. ; Fonseca, M.J.P. ; Souza, T.M.M.
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In the present study, magnetic resonance (MR) and light microscopy (LM) were used to investigate in vitro effects of dextran-coated magnetic nanoparticles (MNPs) on mouse Raw cells. LM showed the increasing internalization and metabolization of MNPs. MR allowed determination of fundamental parameters, such as the MNP internalization half-life (t1/2). The data evidenced that MR can be used as a key spectroscopic technique to investigate MNP internalization and cell/tissue interaction processes in biological systems

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Magnetics, IEEE Transactions on  (Volume:42 ,  Issue: 10 )