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A CMOS contact imager for locating individual cells

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4 Author(s)
Honghao Ji ; Dept. of Electr. & Comput. Eng., Maryland Univ., College Park, MD ; Sander, D. ; Haas, A. ; Abshire, P.A.

We describe the design of a contact imager for applications in lab-on-a-chip systems, such as sample preparation and manipulation and monitoring of cells. This is a challenging task because most cells are nearly transparent, so the contrast between the presence and absence of a cell is small. Thus additional image processing is necessary to locate cells. To enhance the image contrast and facilitate object recognition, the contact imager implements on-chip one bit quantization with a dynamic threshold that adapts to the background illumination. The imager is capable of locating dark objects in a bright background or bright objects in a dark background. The locations of recognized cells are generated as outputs to alleviate computational requirements for generating control signals in closed-loop systems

Published in:

Circuits and Systems, 2006. ISCAS 2006. Proceedings. 2006 IEEE International Symposium on

Date of Conference:

21-24 May 2006

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