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Digital signal processing and modeling of the upstroke of action potential in cardiac myocytes

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5 Author(s)
J. Toyama ; Res. Inst. of Environ. Med., Nagoya Univ., Japan ; T. Anno ; A. Taniguchi ; M. Shirakawa
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A mathematical model was reconstructed based on the upstroke and sodium current separately recorded from enzymatically dispersed ventricular myocytes of a guinea pig, using the patch clamp technique. After holding the membrane potentials ranging from -120 to -60 mV for 500 ms, the upstroke was induced by applying the stimulus through the patch electrode with the constant latency to obtain voltage-dependence of availability for Vmax. Phase plane plots (membrane potential vs. dV/dt) were used for optimization of a mathematical model. Experimental results could be reproduced by the model

Published in:

Computers in Cardiology 1991, Proceedings.

Date of Conference:

23-26 Sep 1991