By Topic

The Spatially Distributed Dynamic Transmembrane Voltage of Cells and Organelles due to 10 ns Pulses: Meshed Transport Networks

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

5 Author(s)
Smith, K.C. ; Div. of Health Sci. & Technol., Harvard-MIT, Cambridge, MA ; Gowrishankar, T.R. ; Esser, A.T. ; Stewart, D.A.
more authors

The authors describe two versions of a two-dimensional (2-D) cell model that contains three circular membranes representing the plasma membrane (PM) and single bilayer approximations to both the nuclear envelope and the mitochondrial membrane. The first version uses a Cartesian transport network, which respects topology but approximates geometry. The second version uses a meshed transport network, which respects both. The asymptotic electroporation model is assigned to all local membrane sites in order to assess the electrical response of the membranes. The predictions of these two models are presented for 10-ns trapezoidal pulses with 1.5 ns rise and fall times. The applied field magnitudes range from 1 to 100 kV/cm, corresponding to recent experiments. The spatially distributed electroporation models exhibit a supraelectroporation for the larger pulses with a maximum transmembrane voltage of Um~1.5 V for both the PM and organelle membranes. For the larger fields, the PM and organelle membranes electroporate essentially simultaneously. The meshed version of the transport network eliminates numerical artifacts and is more computationally efficient

Published in:

Plasma Science, IEEE Transactions on  (Volume:34 ,  Issue: 4 )