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Microdosimetric characteristics of micro X-ray beam for single cell irradiation

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6 Author(s)
T. Kuchimaru ; Div. of Electr., Electron. & Inf. Eng., Osaka Univ., Japan ; F. Sato ; Y. Higashino ; K. Shimizu
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A tabletop micro X-ray beam irradiation system has been developed to study radiation effects on living cells. The microbeam system is composed of a micro focus X-ray tube, a capillary for X-ray guide, an X-ray semiconductor detector for fluorescent X-ray analysis, and an inverted microscope. A beam profile measurement was performed and the size of the focused beam was 10 μm in diameter [full-width at half-maximum (FWHM)] with a divergence of 5.1 mrad. The data on the microbeam measurement were approximately in agreement with a simulation of X-ray optical traces for the capillary. In addition, the microdosimetric characterization for single cell irradiation was performed with the beam profile measurement and a photon-electron transport simulation. The maximum of the dose rate for the sample cells set in the system was estimated to be 0.05 Gy/s. In a preliminary experiment, single yeast cells were irradiated with the X-ray microbeams, and the data on the survival rate of the cell samples for the X-ray doses were obtained. Then, the microbeam irradiation system is useful to investigate the radiation effects on the living cells.

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IEEE Transactions on Nuclear Science  (Volume:53 ,  Issue: 3 )