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Two dimensional phase sensitive surface plasmon resonance biosensor array using microfluidic flow circuit platform

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9 Author(s)
Chi Lok Wong ; Department of Electronic Engineering, The Chinese University of Hong Kong ; Ho Pui Ho ; Kin Fong Lei ; Wen Jung Li
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The integration between 2D SPR differential phase imaging sensor and microfluidic flow circuit is presented. It provides the advantages of high throughput, high sensitivity and label free detection to meet the present needs in biomechnical market. The differential phase scheme between p- and s- polarization enable elimination of all common-path phase noise while keeping the phase change caused by SPR effect. System sensitivity of the detection sensitivity of our setup is 0.44μg /ml is obtained for salt / water mixture sensing. BSA antigen and antibody binding reaction detection is further demonstrated. The system shows the capability of simultaneous detection for both specific and non-specific binding reactions in a micro-chamber array.

Published in:

Electron Devices and Solid-State Circuits, 2005 IEEE Conference on

Date of Conference:

19-21 Dec. 2005