By Topic

Nonlinear Electrophoretic Mobility of Large DNA Molecules in Microsystems with Sub-Micron Pillar Arrays

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

3 Author(s)
Yick Chuen Chan ; Department of Mechanical Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong ; Zohar, Y. ; Yi-Kuen Lee

This paper presents a systematic study of free-solution electrophoretic motion of large DNA molecules in microsystems integrated with sub-micron pillar arrays. A nonlinear dependence of the DNA electrophoretic mobility on the applied electric field is observed. The interaction between DNA molecules and the pillar arrays is inspected under high optical magnification. Several distinct DNA molecular motions at different electric fields, associated with the DNA nonlinear response, are identified. The measured free-solution DNA mobility, inside the pillar arrays, has been found to be within the prediction range based on the Biased Reptation with Fluctuations Model.

Published in:

Micro Electro Mechanical Systems, 2006. MEMS 2006 Istanbul. 19th IEEE International Conference on

Date of Conference:

2006