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Discrete Chemical Release From a microfluidic Chip

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6 Author(s)
Hu, M. ; University of Freiburg - IMTEK, Laboratory for MEMS Applications, Georges-Koehler-Allee 106, D-79110 Freiburg, Germany, e-mail: ; Lindemann, T. ; Gottsche, T. ; Kohnle, J.
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Controlled chemical release has many applications, including treatment for diabetes and stimulation of neurons. In this paper we present a discrete chemical release method capable of delivering picoliter volumes of chemical solutions with 100 µ m spatial and 20 µ s temporal resolution. The releasing mechanism is based on the transfer of discrete picoliter sized liquid droplets from an ejecting nozzle to a receiving aperture, through an air-trapped hydrophobic chamber. This new method could be a key enabling technology for the precisely controlled release of biochemicals, like potent drugs and neurotransmitters, for modern clinical therapeutics and biological research.

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Micro Electro Mechanical Systems, 2006. MEMS 2006 Istanbul. 19th IEEE International Conference on

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