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MEMS Based Sensors for the Study of Indentation Response of Single Cells

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2 Author(s)
Shengyuan Yang ; Department of Mechanical and Industrial Engineering, University of Illinois at Urbana-Champaign, 1206 West Green Street, Urbana, Illinois 61801, USA ; T. Saif

This paper presents bioMEMS force sensors, consisting of a probe and flexible beams, to study mechanobiological response of single living cells subjected to mechanical injury. Mechanical injuries are simulated by the application of large indentation on the cells by the sensor probe. The green fluorescent protein (GFP) technique is used to visualize the evolution of the actin network in the cells. The lateral indentation force response measurement capability of the sensors is shown. Two new types of remodeling, large buckling of stress fibers and actin agglomeration, in the actin network in a cell due to mechanical stimuli are reported.

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19th IEEE International Conference on Micro Electro Mechanical Systems

Date of Conference: