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Densensitization, or the blocking of the receiver portion of the communications system, is one of the principal causes limiting receiver operation, especially in mobile networks under cositing situations. A clear understanding of this nonlinear effect is thus essential when attempting to improve the reliability of mobile radio communication systems so as to prevent severe interferences. A thorough qualitative analysis of desensitization effects on receiver parameters is provided and semi-empirical and statistical relationships useful for performing quantitative computations are developed. The developed analysis initially treats the computation of desensitization effects on radio communication system scenarios for both a single interfering transmitter and several simultaneous interfering transmitters. The results of this qualitative analysis then allow us to compute quantitatively the desensitization effects of a typical mobile radio system which are presented in a second paper.