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Effects of Large Blood Vessel Locations during High Intensity Focused Ultrasound Therapy for Hepatic Tumors: a finite element study

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4 Author(s)
C. X. Zhang ; Institute of Biomedical Instrument, Shanghai Jiao Tong University, Shanghai, China ; Z. Zhang ; Z. Zhang ; Y. Z. Chen

High-intensity focused ultrasound (HIFU) has become a viable alternative for treatment of primary and metastatic liver tumors. We evaluated the effects of presence of a large blood vessel and its distance to the tumor on lesion size during HIFU heating. A finite element method (FEM) was used to obtain the temperature distribution for a transfer equation based on large blood vessels convection effect. In 3-D FEM simulation, a 4-mm diameter, 10-mm height cylindrical tumor tissue was heated by different heating schemes with a large blood vessel (10-mm diameter) located at different positions nearby. The distance between the vessel and the tumor tissue varied from 1 mm to 3 mm. For HIFU therapy, the large blood vessel of different locations do not have significant effect on temperature distribution and thermal dose profile, when the heating duration is short (~2s) or the distance of the large blood vessel from the tumor is larger than 2 mm. The domain of thermal lesion can effectively cover the desired therapeutic region with short ultrasound exposure duration (~2s)

Published in:

2005 IEEE Engineering in Medicine and Biology 27th Annual Conference

Date of Conference:

17-18 Jan. 2006