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A CMOS optical/potential image sensor with 7.5 μm pixel size for on-chip neural and DNA spot sensing

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6 Author(s)
T. Tokuda ; Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, Japan ; D. C. Ng ; A. Yamamoto ; K. Kagawa
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An optical/potential CMOS image sensor was designed and fabricated for bioimaging applications. The image sensor is capable to simultaneously sense an optical image and an on-chip potential image. Target applications of the sensor are on-chip (optical + potential) neural imaging and on-chip DNA microarray sensing. The sensor has a QCIF (176 times 144) pixel array with alternatively aligned optical/potential sensing pixels. The pixel size is 7.5 mum times 7.5 mum. The potential resolution is confirmed to be better than 10 mV. An on-chip fluorescence imaging of a mouse's hippocampus was performed to demonstrate that fluorescence imaging is possible with on-chip configuration

Published in:

2005 IEEE Engineering in Medicine and Biology 27th Annual Conference

Date of Conference:

17-18 Jan. 2006