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Study of 99mTc-TRODAT-1 imaging on human brain with children autism by single photon emission computed tomography

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5 Author(s)
Sun Xiao-mian ; Inst. of Biomed. Eng., Xi''an Jiaotong Univ. ; Yue Jing ; Liu Min ; Deng Hui-xing
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To evaluate the application values of 99mTc-2 beta[N, N'-bis(2-mercaptoethyl) ethylenediamino] methyl, 3 beta-(4-chlorophenyl) tropane (TRODAT-1) dopamine transporter (DAT) SPECT imaging in children autism, and offer the academic foundation to etiology, mechanism and clinical therapy of autism. Ten autistic children and ten healthy controls were examined with 99mTc-TRODAT-1DAT SPECT imaging. Striatal specific uptake of 99mTc-TRODAT-1 was calculated with region of interest analysis according to the ratios between striatum and cerebellum [(STR-BKG)/BKG]. There was no difference in semiquantitative dopamine transporter between bilateral striatum in autistic children (p=0.562) and in normal controls (p=0.573); Dopamine transporter in brain of patients with autism increased significantly than that in normal controls (p=0.017). Dopaminergic nervous system is dysfunction in human brain with children autism, and DAT 99mTc-TRODAT-1 SPECT imaging on human brain will help the imaging diagnosis of children autism

Published in:

Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the

Date of Conference:

17-18 Jan. 2006