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A Novel Porous Natural Polymer Scaffold for Tissue Engineering

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4 Author(s)
Shengju Gong ; Coll. of Life Sci. & Biotechnology, Shanghai Jiao Tong Univ. ; Jian Dong ; Song-Tao Xue ; Jin-Ye Wan

A novel porous polymer scaffold fabricated by salt-leaching method for tissue engineering was developed and the mechanical properties and porosity were investigated in our study. Scanning electronic microscopy (SEM) was employed to observe the morphology and structure of porous scaffolds. Cytocompatibility of the porous scaffolds were evaluated, using HL-7702 cells as model, in terms of cell attachment and cell viabilities from 3 to 72 hours determined by MTT method. These scaffolds possessed a total porosity of 64.2%, compressive Young's modulus of (31.8plusmn6.5) MPa. The particle size of porogen has little effect on the compressive properties and porosities. In addition, the morphology of pores observed by SEM showed good pore interconnectivity within the porous scaffolds. HL-7702 cell viabilities kept at high level during the whole incubation period

Published in:

Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the

Date of Conference:

17-18 Jan. 2006