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A species-specific biosensor is presented based on the combined use of a reflection mode long period fibre grating with nanoscale self-assembly. Self-assembled polyelectrolyte layers and the immobilisation of immunoglobulin G (IgG) were used for sensor fabrication. The sensor's fringe position shift induced by specific antigen-antibody binding has been observed, and non-specific binding was minimised with binding block. The results show the feasibility of the sensor for various bio/chemical applications.
Date of Publication: 16 March 2006