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This paper focuses on the interaction between the transport control protocol (TCP) layer and the radio interface in the high-speed downlink packet access (HSDPA) wireless system. In the literature, studies of the interaction between TCP and wireless networks are focused on the evaluation of user bit rate in the case of dedicated channels. In this paper, the interaction between TCP, hybrid automatic repeat request (HARQ), and scheduling techniques (especially, proportional fair scheduling) is conducted. Analytical models to evaluate HSDPA cell capacity, user bit rate, and interaction with TCP layer are presented. Even if as expected the bit rate per flow decreases strongly with the congestion frequency in the wired network, it is shown that the overall capacity achieved by HSDPA is not as affected by the TCP layer. Using this result, a method to reduce the effect of TCP on wireless network without losing much cell capacity is proposed. This method has the advantage of modifying the scheduling algorithm only and of not requiring any change to the TCP protocol.