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Monte Carlo simulation study of a dual-plate PET camera dedicated to breast cancer imaging

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5 Author(s)
Jin Zhang ; PerkinElmer Optoelectron., Santa Clara, CA, USA ; P. D. Olcott ; A. M. K. Foudray ; G. Chinn
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We studied the performance of a dual-plate positron emission tomography (PET) camera dedicated to breast cancer imaging using Monte Carlo simulation based on GATE open code software. The PET camera under development has two 10times15 cm2 plates that are constructed from arrays of 1times1times3 mm3 LSO crystals coupled to novel silicon-based ultra-thin (<300 mum) position-sensitive avalanche photodiodes (PSAPD). With the photodetector configured "edge-on", incoming photons see effectively 2-cm-thick of LSO with directly measured 3-mm photon depth-of-interaction. Simulations predict that this camera will have >10% sensitivity, and detector measurements show ~1 mm3 intrinsic spatial resolution, <12% energy resolution, and ~2 ns coincidence time resolution. With a breast phantom including breast, heart and torso activity (concentration ratio of 1:10:1, respectively), count performance was studied under varying time and energy windows. We also studied visualization of hot spheres within the breast for 1times1times3 mm3, 2times2times10 mm3, 3times3times30 mm3 and 4times4times20 mm3 crystal resolutions at different plate separations. Images were reconstructed by focal plane tomography and 3D OS-EM with attenuation and solid angle corrections applied. With an activity concentration ratio of tumor:breast:heart:torso of 10:1:10:1, only the dual-plate PET camera comprising 1times1times3 mm3 crystals can resolve 2.5-mm tumor spheres with an average peak-to-valley ratio of 1.3 in only 30 seconds of acquisition time

Published in:

IEEE Nuclear Science Symposium Conference Record, 2005  (Volume:3 )

Date of Conference:

23-29 Oct. 2005