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This article provides the principles and practice of how interference cancellation can be implemented on the EV-DO Rev A reverse link. It is shown that applying interference cancellation to CDMA achieves the multiple access channel sum rate capacity for either frame synchronous or asynchronous users. The per user SINR gain from space-time interference cancellation translates directly into a CDMA capacity gain of the same factor, allowing EV-DO Rev A to support more users with higher data rates. We demonstrate how interference cancellation can be added to base station processing without modifying user terminals, EV-DO standards, or network coverage. We present commercially viable receiver architectures for implementing interference cancellation with the asynchronism and H-ARQ of EV-DO RevA, and explain why closed loop power control can operate the same way it does today. Network level simulations over a wide range of channels confirm that interference cancellation offers significant capacity gains for all users, while maintaining the same link budget and system stability.