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A short proof that phylogenetic tree reconstruction by maximum likelihood is hard

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1 Author(s)
S. Roch ; Dept. of Stat., California Univ., Berkeley, CA, USA

Maximum likelihood is one of the most widely used techniques to infer evolutionary histories. Although it is thought to be intractable, a proof of its hardness has been lacking. Here, we give a short proof that computing the maximum likelihood tree is NP-hard by exploiting a connection between likelihood and parsimony observed by Tuffley and Steel

Published in:

IEEE/ACM Transactions on Computational Biology and Bioinformatics  (Volume:3 ,  Issue: 1 )