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Classification of Escherichia coli K-12 ribosome binding sites

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3 Author(s)
E. E. May ; Sandia Nat. Labs., Albuquerque, NM, USA ; M. A. Vouk ; D. L. Bitzer

Drawing on parallels between genetic information processing in living organisms and the processing of communications data, we develop an error-control coding-based translation initiation classification system that uses an eleven base classification window. An overview of channel codes and a summary of the translation initiation process are presented. Parallels between the two are drawn and a brief review of a channel code model for translation initiation is shown. A block-code Bayesian classifier is presented and the results of applying the system to the translation start site location problem for Escherichia coli K-12 is discussed.

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IEEE Engineering in Medicine and Biology Magazine  (Volume:25 ,  Issue: 1 )